Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains
Claire J. LeBlanc, Jordan Stefani, Melvin Soriano, Angelica Lam, Marissa A. Zintel, Sanjana R. Kotha, Emily Chase, Giovani Pimentel-Solorio, Aditya Vunnum, G.F. Hu, Katherine Flug, Aaron Fultineer, Niklas F. C. Hummel, Max Valentín Staller
The paper shows that function can be conserved in transcriptional activation domains without sequence conservation through evolutionary turnover of key residues.
PLoS Genetics · Mar 16, 2026Peer-reviewedSystems Biology