Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS)
Tricia R. Cottrell, Jeffrey S. Roskes, Michael Fotheringham, Emily Cohen, Boyang Zhang, Logan L Engle, Daphne Wang, Elizabeth Will, Joel Chaim Sunshine, Daniel Jiménez‐Sánchez, Zhen Zeng, Justina X. Caushi, Jiajia Zhang, Nina M. D’Amiano, Julie Stein Deutsch, , Janis Marie Taube
The paper develops a spatial biomarker, DONUTS, to predict treatment response in lung cancer by analyzing the niche surrounding CD8+FoxP3+ T-cells.
bioRxiv · Aug 13, 2025 · PreprintPathology