Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington’s disease
Robert M. Bragg, Sydney R. Coffey, Rory M. Weston, Seth A. Ament, Jeffrey P. Cantle, Shawn Minnig, Cory C. Funk, Dominic D. Shuttleworth, Emily L. Woods, Bonnie R. Sullivan, Lindsey Jones, Anne Glickenhaus, John S. Anderson, Michael D. Anderson, Stephen B. Dunnett, , Jeffrey B. Carroll
This study shows that B6.HttQ111/+ mice exhibit early transcriptional and proteostatic deficits before synapse loss and neurodegeneration in HD.
Scientific Reports · Feb 8, 2017Peer-reviewedNeuroscience