Amino acid exchangeability and surface accessibility underpin the effects of single substitutions
Berk A. Alpay, Piyush Nanda, Emma Nagy, Michael M. Desai
The paper performs a statistical meta-analysis of single amino acid substitutions using deep mutational scans to quantify physicochemical trends and derive an empirical amino acid exchangeability matrix.
Genetics · Apr 21, 2026Peer-reviewedBioinformatics