Why don't transcription factors exploit inter-nucleotide correlations in binding motifs? Evolution of information encoding strategies on DNA
Emmanuel Mekasha, Elia Mascolo, Ivan Erill
This study investigates why transcription factors use simple, uncorrelated binding motifs despite potential benefits of correlated ones, finding that simpler strategies are more robust to mutations.
bioRxiv · Nov 10, 2026 · PreprintEvolutionary Biology