ADAR RNA editing for cardiovascular disease: Targeting B4GALT1 to modulate lipid metabolism through reduced galactosyltransferase activity
Francesco De Chiara, Eva Coll-de la Rubia, Petra de Bruijn, Galja Pletikapic, Nicole H.P. Cnubben, Lianne J. Stevens, Emy Theunissen, Janne J. Turunen, Anita M. van den Hoek, Hans M. G. Princen, Wouter Beumer, Seda Yilmaz-Elis, Bart Klein, Sjef J. de Kimpe, Gerard J. Platenburg
This study uses RNA editing to target B4GALT1 in mice, reducing lipid levels and coagulation factors without altering gene expression, suggesting potential for cardiovascular disease therapy.
Molecular Therapy — Nucleic Acids · Jul 9, 2026Peer-reviewedGenetics