Charting the undiscovered metabolome with synthetic multiplexing implicates ibuprofen-carnitine in myotoxicity
Abubaker Patan, Shipei Xing, Vincent Charron‐Lamoureux, Zhewen Hu, Victoria Deleray, Julius Agongo, Jasmine Zemlin, Harsha Gouda, Prajit Rajkumar, Yasin El Abiead, Aubreyana E. McMaugh, Hannah Heath, Helena Mannochio-Russo, Ipsita Mohanty, Laila Abolfathi, , Pieter C. Dorrestein
The paper uses synthetic multiplexing to annotate uncharacterized metabolites, identifying ibuprofen-carnitine as a metabolite linked to muscle toxicity.
bioRxiv · Nov 18, 2025 · PreprintBiochemistry