drug response / drug discovery

This study uses chromosome-level genomics and cross-species enzyme screening to enhance bakuchiol production in Yarrowia lipolytica through metabolic engineering.

This paper shows that mitochondrial dysfunction triggers a translational stress response via GCN2 kinase, leading to diabetic pain, and demonstrates interventions to block this pathway.

This study develops a task to measure both intrinsic and extrinsic motivation and finds that drugs affect these motivations differently, highlighting pharmacological divergence.

This study identifies Posaconazole binding sites on PeV-A3 capsid proteins and shows how variants reduce drug efficacy by altering binding interactions.

This study evaluates the reproducibility and cross-dataset consistency of drug-induced transcriptional responses across six resources, identifying drug main effects as a key bottleneck.

This paper establishes new disease models for SynGAP1-related disorder using patient-derived hiPSCs and humanized knock-in mice to study the effects of a SYNGAP1 nonsense mutation.

This paper develops a reinforcement learning framework to determine optimal stimulation timing for seizure termination in a Morris-Lecar network, showing learned policies reduce seizure duration compared to controls.

This study introduces a computational framework for designing antibodies that target multiple antigenic variants, including observed and forecasted ones, and demonstrates its effectiveness against cancer and viral antigens.

This paper develops a luciferase reporter system to measure ester prodrug delivery and hydrolysis in mycobacteria, showing that permeation and intracellular unmasking depend on chain length and branching, respectively.

This study identifies a metabolic vulnerability in NRF2-hyperactive cancers where selenite induces cell death by disrupting mitochondrial function and redox balance.

This paper introduces GFM, a generative framework that predicts single-cell transcriptomes after genetic perturbations using biological knowledge graphs, outperforming existing methods and demonstrating robustness with limited data.

This study shows that ZP12, a zwitterionic polymer, effectively inhibits alphavirus infection in Aedes mosquitoes both in vitro and ex vivo, with potent virucidal activity.

The paper develops a mathematical model to link appetite-driven food intake to metabolic changes in mice across diets and GLP-1RA treatments, showing predictive validity across multiple studies.

The paper identifies ROR1 activation as a key pathway mediating the protective effects of NMDAR antagonists on pancreatic islet cells through phosphoproteomics and kinase profiling.

This study shows HPV oncogenes alter DNA repair mechanisms in HNSCC, creating a vulnerability to therapies targeting RAD51 filament dynamics.

The paper develops RIZLiver to infer zonal identity from gene expression in liver disease, showing loss of zone-3 identity in MASLD and therapeutic potential through zonal restoration.

This paper identifies three therapeutic axes for MBD4-deficient tumors using a multi-layered framework, showing sensitivity to ATR inhibitors and cytidine analogs but not PARP inhibitors.

This paper develops a method to sustain Tie2 activation using engineered mRNA, showing improved endothelial stabilization compared to traditional ligands.

This study shows that SOX7 and ERG reprogram human pluripotent stem cell-derived cells into brain endothelial cells with forebrain regional bias, improving BBB modeling.

This study identifies S100A4 as a targetable regulator of immune suppression in glioblastoma, showing its inhibition enhances immunotherapy response and survival.

This study develops a CNTF-VG1 fusion protein to extend ocular retention of CNTF, showing improved vitreous stability and neuroprotection in glaucoma models.

This paper demonstrates efficient transient gene delivery into primary Schwann cells using circular RNA delivered by Listeria monocytogenes drones, achieving high bactofection efficiency with minimal cell death.

The paper identifies LCK-driven EGFR activation as a therapeutic target in cholangiocarcinoma, showing EGFR activity predicts response to EGFR inhibition.

This study engineers the thumb loop of T7 RNA polymerase to enhance the integrity of long RNA transcripts, identifying specific substitutions that improve stability across different transcript lengths.

Pallatom2 is a generative model for protein design that achieves high-affinity binder discovery and experimental success across multiple targets.

This study demonstrates tetracycline-responsive aptazymes that control saRNA expression levels, showing reduced eGFP expression with Tet-On and Tet-Off systems.

This paper engineers the CasX-Editor to create a more potent and specific genome editor for therapeutic use, showing improved activity and reduced off-target effects in nonhuman primates.

The paper presents RES-Q, a network of wearable sensors and syringe-implantable autoinjectors for closed-loop therapy, demonstrating rapid overdose rescue in rats.

This paper introduces stochprofIC, an algorithm for noise-corrected state variability inference in single cells, validated using mini-bulk data from mouse brains and human breast cancers.

The paper decomposes gene coexpression networks into cell type-specific and shared components, showing that specific networks funnel genetic risk into core disease genes.