Environmental co-option of chromatin potential links prenatal hypoxia to persistent cortical circuit dysfunction
Ana G. Cristancho, Donald J. Joseph, Margaret M. Cassidy, Preeti Chauhan, Ethan J. Gadra, Elyse C. Gadra, Donya Zarrinnegar, Bianca N. Rodriguez, Eric D. Marsh
The paper investigates how transient prenatal hypoxia affects chromatin accessibility and transcriptional responses in mouse cortical neurons, linking these changes to long-term circuit dysfunction.
bioRxiv · Nov 28, 2025 · PreprintNeuroscience