F. Jiao

Geometry theory of distribution shapes for autoregulatory gene circuits

This study mathematically characterizes the phase diagram of protein distribution shapes in autoregulatory gene circuits, identifying three steady-state shapes and their parameter regions.

What can we learn when fitting a simple telegraph model to a complex gene expression model?

The paper fits a simple telegraph model to complex gene expression models to infer effective parameters and reveal underlying regulatory mechanisms using single-cell data from E. coli and mammalian cells.

Framework estimation of stochastic gene activation using transcription average level

This paper estimates gene activation frameworks and system parameters using average transcription level data, revealing distinct regulation scenarios in mouse fibroblast genes.