Unraveling the Impact of W215A/E217A Mutations on Thrombin Dynamics and Thrombomodulin Binding through Molecular Dynamics Simulations
This study uses molecular dynamics simulations to analyze how W215A/E217A mutations affect thrombin's substrate specificity and TM binding, revealing structural changes and identifying ARG125 as a key residue.
bioRxiv · Dec 20, 2023 · PreprintBiophysics