Proton sponge or membrane fusion? Endosomal escape of siRNA polyplexes illuminated by molecular dynamics simulations
Katharina M. Steinegger, Min Jiang, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel
This study uses molecular dynamics simulations to analyze endosomal escape mechanisms of siRNA polyplexes and a lipid nanoparticle, identifying key interactions that correlate with in vitro performance.
bioRxiv · Mar 16, 2026 · PreprintBioengineering