An Energy Landscape Approach to Miniaturizing Enzymes using Protein Language Model Embeddings
Jakub Lála, Harsh Agrawal, Fanfei Dong, Jude Wells, Stefano Angioletti‐Uberti
The paper uses a PLM-guided energy landscape approach to design compact enzymes with preserved catalytic site structures, validated through structure prediction and molecular dynamics simulations.
bioRxiv · Mar 5, 2026 · PreprintBioinformatics