Author

Franck Rapaport

Rockefeller University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Étienne PatiniD· 2 shared Jean‐Laurent CasanovaiD· 2 shared Laurent AbeliD· 2 shared Lluís Quintana‐MurciiD· 2 shared Anne GregoriD· 1 shared Anne PueliD· 1 shared Antoine FavieriD· 1 shared Antonio RauselliD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetics

Étienne PatinORCID

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2 papers

Recent·Most cited

Negative selection on human genes causing severe inborn errors depends on disease outcome and both the mode and mechanism of inheritance

Franck Rapaport, Bertrand Boisson, Anne Gregor, Vivien Béziat, Stéphanie Boisson‐Dupuis, Jacinta C. Bustamante, Emmanuelle Jouanguy, Anne Puel, Jérémie Rosain, Qian Zhang, Shen‐Ying Zhang, Joseph G. Gleeson, Lluís Quintana‐Murci, Jean‐Laurent Casanova, Laurent Abel, Étienne Patin

The paper develops CoNeS to assess negative selection on genes causing severe inborn errors, finding that disease outcome and inheritance mode/mechanism influence selection strength.

Proceedings of the National Academy of Sciences · Jan 6, 2021Peer-reviewedGenetics

Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes

Antonio Rausell, Yufei Luo, Marie Lopez, Yoann Seeleuthner, Franck Rapaport, Antoine Favier, Peter D. Stenson, D.N. Cooper, Étienne Patin, Jean‐Laurent Casanova, Lluís Quintana‐Murci, Laurent Abel

The paper identifies 166 dispensable human genes with common loss-of-function variants that show relaxed selective constraints and some evidence of positive selection.

Proceedings of the National Academy of Sciences · Jun 2, 2020Peer-reviewedGenetics