Disturbance of poised chromatin coincides with increased expression of developmental genes in cancer
Stephan H Bernhart, Helene Kretzmer, Frank Jühling, Peter F Stadler, Steve Hoffmann
The paper shows that hypermethylation of poised chromatin and up-regulation of corresponding developmental genes is a common feature in cancer, using large-scale expression and methylation data.
bioRxiv · Mar 29, 2015 · PreprintCancer Biology