Myelin Governs Hippocampal Network Function through the Extracellular Space it Occupies, Not Only the Axons it Insulates
Xin Jia, Cuidie Zeng, Linchen Liu, Tengao Gao, Jing Bi, Zhiming Zeng, Lei Liang, Chenxiang Qi, Fuyuan Lin, Fangxiao Cheng
This study shows that myelin affects hippocampal network function by shaping extracellular space, not only by insulating axons, with demyelination altering diffusion, flow, and synaptic transmission.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience