Risk factors affecting polygenic score performance across diverse cohorts
Daniel Hui, SCOTT M. DUDEK, Krzysztof Kiryluk, Theresa L. Walunas, Iftikhar J. Kullo, Wei‐Qi Wei, Hemant K. Tiwari, Josh F. Peterson, Wendy K. Chung, Brittney H. Davis, Atlas Khan, Leah Claire Kottyan, Nita A. Limdi, QiPing Feng, Megan J. Puckelwartz, , Marylyn DeRiggi Ritchie
The paper examines how covariates affect polygenic score performance across European and African cohorts, finding significant differences in R2 and interaction effects, and proposes methods to improve model performance.
eLife · Jan 24, 2025Peer-reviewedGenetic & Genomic Medicine