Daniel Hui

Risk factors affecting polygenic score performance across diverse cohorts

The paper examines how covariates affect polygenic score performance across European and African cohorts, finding significant differences in R2 and interaction effects, and proposes methods to improve model performance.

Mendelian randomization analyses clarify the effects of height on cardiovascular diseases

This study uses Mendelian randomization to assess the causal effect of height on cardiovascular diseases, finding that established risk factors largely explain the association, with minimal residual effect.

Cell type- and state- resolved immune transcriptomic profiling identifies glucocorticoid-responsive molecular defects in multiple sclerosis T cells

The paper identifies glucocorticoid-responsive molecular defects in MS T cells through cell-type-specific transcriptomic profiling and validates potential therapeutic targets.

Non-parametric polygenic risk prediction using partitioned GWAS summary statistics

This paper introduces a non-parametric polygenic risk prediction method using GWAS summary statistics, improving prediction accuracy for several diseases.