Morphology-Aware Profiling of Highly Multiplexed Tissue Images using Variational Autoencoders
Gregory J. Baker, Edward Novikov, Shannon Coy, Yu‐An Chen, Clemens B. Hug, Zergham Ahmed, Sebastián Andrés Cajas, Siyu Huang, Clarence Yapp, Gaurav N. Joshi, Fumiki Yanagawa, Artem Sokolov, Hanspeter Pfister, Sandro Santagata, Peter Karl Sorger
This paper introduces a method that combines autoencoders with segmentation to improve single-cell analysis of multiplexed tissue images by capturing morphology and reducing signal spillover.
bioRxiv · Jun 23, 2025 · PreprintPathology