Anticipatory metabolic reprogramming distinguishes caloric restriction from fasting-refeeding cycles
Nikkhil Velingkaar, A. A. Astaf’ev, Archana Prabahar, Evelina Trokhimenko, Josefa-Marie B. Rom, Gena J Asi, Peng Jiang, Roman V. Kondratov
This study compares caloric restriction (CR) and fasting-refeeding (FRF) in mice, finding that CR uses anticipatory metabolic control while FRF relies on direct nutrient cues.
bioRxiv · Mar 18, 2026 · PreprintMolecular Biology