A Simple Method to Distinguish Active and Inactive Aptamers by Analyzing the Ruggedness of the Aptamer Free Energy Landscape
Gopalakrishnan Subramanian, William Thiel, Rahul Singh
The paper introduces RCI to distinguish active from inactive aptamers by analyzing their free energy landscape ruggedness, showing active aptamers have smoother landscapes and lower RCI values.
bioRxiv · Aug 29, 2026 · PreprintBioinformatics