Temporal Stability and Molecular Persistence of the Bone Marrow Plasma Cell Antibody Repertoire
Gabriel Wu, Nai-Kong Cheung, George Georgiou, Edward Marcotte, Gregory C Ippolito
This study shows that the bone marrow plasma cell antibody repertoire remains stable over 6.5 years, with persistent clonal clusters and gene usage patterns, suggesting intrinsic longevity of plasma cells and a basis for serological memory.
bioRxiv · Aug 2, 2016Immunology