Homology-aware cross-validation strategies for generalization assessment in RNA secondary structure prediction
Leandro A. Bugnon, Guillermo Kulemeyer, Matias Gerard, Leandro Ezequiel Di Persia, Georgina S. Stegmayer, Diego Humberto Milone
The paper evaluates cross-validation strategies for RNA secondary structure prediction, showing that current methods bias results and proposing homology-aware strategies for fair comparison.
bioRxiv · Jun 29, 2026 · PreprintBioinformatics