Geographic heterogeneity impacts drug resistance predictions in Mycobacterium tuberculosis
Guo Liang Gan, Matthew H. Nguyen, Elijah Willie, Mohammad H. Rezaie, Brian Lee, Cédric Chauve, Maxwell W. Libbrecht, Leonid Chindelevitch
This study uses machine learning on whole-genome sequencing data from multiple geographic regions to predict drug resistance in Mycobacterium tuberculosis, finding that performance varies across datasets due to geographical heterogeneity.
bioRxiv · Sep 17, 2020 · PreprintBioinformatics