Annotation and differential analysis of alternative splicing using de novo assembly of RNAseq data
Clara Benoit-Pilven, Camille Marchet, Emilie Chautard, Leandro Lima, Marie-Pierre Lambert, Gustavo Sacomoto, Amandine Rey, Cyril Bourgeois, Didier Auboeuf, Vincent Lacroix
This study compares mapping-first and assembly-first approaches for annotating and differentially analyzing alternative splicing from RNAseq data, showing complementary strengths and advocating their combined use.
bioRxiv · Sep 12, 2016Bioinformatics