Comparison of hiPSC-derived hepatic organoids and liver-on-a-chip systems reveal microenvironment-driven maturation
Isabel Tamargo-Rubio, Tim Krempel, Victoria E.J.M. Palasantzas, Bella Green, Gwen Weijer, Renée Moerkens, Channen van der Woude, Sven CD van IJzendoorn, Daan Johannes Touw, Joanne A. Hoogerland, Sebo Withoff, Jingyuan Fu
This study compares hiPSC-derived hepatic organoids and liver-on-a-chip systems, showing that microfluidic flow enhances hepatic maturation and metabolic specialization.
bioRxiv · Jul 29, 2026 · PreprintCell Biology