Distinct rates of VUS reclassification are observed when subclassifying VUS by evidence level
Gwendolyn Bennett, Izabela Karbassi, Wenjie Chen, Steven M. Harrison, Matthew S. Lebo, Linyan Meng, Narasimhan Nagan, Robert Rigobello, Heidi L. Rehm
The paper examines how variants of uncertain significance (VUS) are reclassified based on subclassification evidence levels across four clinical laboratories.
Genetics in Medicine · Feb 28, 2025Peer-reviewedGenetic & Genomic Medicine