Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts
Y. Buganim, M. Naama, A. Radwan, V. Zayat, S. Sebban, M. Rahamim, R. Lasry, M. Jaber, O. Sabag, H. Yassen, D. Orzech, A. Khatib, S. Epsztejn-Litman, M. Novoselsky-Persky, K. Makedonski, , R. Eiges
This study identifies GOKM factors that can generate functional hiTSCs independently of pluripotency factors, showing distinct chromatin and gene expression profiles compared to OSKM-induced cells.
bioRxiv · Nov 10, 2021Cell Biology