Probing recombinant AAV capsid integrity and genome release under thermal stress by single-molecule interferometric scattering microscopy
E. H. T. M. Ebberink, A. Ruisinger, M. Nuebel, H. Meyer-Berg, I. R. S. Ferreira, M. Thomann, A. J. R. Heck
This study uses single-molecule interferometric scattering microscopy to analyze AAV capsid stability and genome release under thermal stress, revealing AAV-specific uncoating behaviors.
bioRxiv · Mar 7, 2024 · PreprintBiophysics