Characterizing antibodies binding to the same epitope reveals limited contribution by heavy chain CDR3 sequences relative to other CDRs
Jarjapu Mahita, Haeuk Kim, Marcus Fabiano de Almeida Mendes, Eve Richardson, Jason Greenbaum, Alessandro Sette, Morten Nielsen, Bjoern Peters
The paper identifies that CDR1 and CDR2 sequence identities are more predictive of epitope similarity than CDR3, and develops BCRMatch to predict epitope binding based on antibody sequences.
bioRxiv · May 24, 2025 · PreprintBioinformatics