Injury-induced CTE-like pathology emerges in a human multicellular in vitro brain model and reveals mitochondrial and neurovascular regulation.
Sunghyun Jun, Daniel S Hinrichsen, Sahan B. S. Kansakar, Charitha C Anamala, Jada Teregeyo, Haiden C Roberts, Colleen Arrasmith, Mitchell D Thielen, Volha Liaudanskaya
This paper develops a human multicellular in vitro brain model that mimics CTE-like pathology after mechanical injury and identifies mitochondrial and neurovascular dysregulation as key features.
bioRxiv · Dec 29, 2025 · PreprintNeuroscience