Unsupervised protein language models learn patterns of enzyme function
Matthew Penner, Michal Lihan, Hannes Bormke, Peter Nix, Hanna Moscho, Paul Dupree, Florian Hollfelder
This paper introduces a framework using protein language models to discover novel enzymes with specific functions by clustering sequence embeddings and recursively exploring functional reservoirs.
bioRxiv · Apr 23, 2026 · PreprintSynthetic Biology