Towards generalizable prediction of antibody thermostability using machine learning on sequence and structure features
Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine Elaine Tinberg, , Kathy Y. Wei
This paper develops machine learning models to predict antibody thermostability using sequence and structure features, showing better generalization with a CNN over pre-trained language models.
mAbs · Jan 22, 2023Peer-reviewedBioinformatics