Early oligodendrocyte dysfunction signature in Alzheimer's disease: Insights from DNA methylomics and transcriptomics
Katherine Fodder, Hannah M. G. Smith, Ümran Yaman, Ignazio Stefano Piras, Megha N. Murthy, John Hardy, Tammaryn Lashley, Rohan de Silva, Dervis A. M. Salih, Conceição Bettencourt
The paper identifies an oligodendrocyte DNA methylation signature in Alzheimer's disease that is preserved across brain regions and disease stages, and is associated with altered gene expression in OLGs.
Molecular Psychiatry · Jun 18, 2026Peer-reviewedNeuroscience