Mapping disease critical spatially variable gene programs by integrating spatial transcriptomics with human genetics
Hanbyul Lee, Haochen Sun, Xuewei Cao, Berke Karaahmet, Zhijian Li, Hans Ulrich-Klein, Mariko F. Taga, Gao T. Wang, Philip L. De Jager, David Alan Bennett, Luca Pinello, Xin Jin, Rahul Mazumder, Kushal K. Dey
Spacelink integrates spatial transcriptomics with genetics to identify spatially variable genes linked to disease, showing improved detection power and disease informativeness.
bioRxiv · Sep 24, 2025 · PreprintGenomics