Evolutionary context-integrated deep sequence modeling for protein engineering
Yunan Luo, Lam Tung Vo, Hantian Ding, Yufeng Su, Yang Liu, Wesley Wei Qian, Huimin Zhao, Jian Peng
This paper introduces ECNet, a deep learning model that uses evolutionary context to predict protein variant fitness, outperforming existing methods on multiple datasets.
Lecture notes in computer science · Jan 1, 2020Peer-reviewedBioinformatics