Single-molecule imaging and tracking on clinical liquid biopsies reveals cancer biomarkers nanoscale organization and heterogeneity
Marrit M. E. Tholen, Roger Riera, Tijmen H. W. Hijzelaar, Hao Cao, Francesca Cortopassi, Meike E. Moers, Mitko Veta, Marjan J. Cruijsen, Daan van de Kerkhof, Volkher Scharnhorst, Lorenzo Albertazzi
This paper develops a method to analyze cancer biomarkers at the nanoscale using single-molecule imaging on clinical liquid biopsies, revealing patient-specific heterogeneity and enabling cancer cell classification.
bioRxiv · Apr 15, 2026 · PreprintBiophysics