Ultra-precision deconvolution of spatial transcriptomics decodes immune heterogeneity and fate-defining programs in tissues
Yin Xu, Zurui Huang, Yawei Zhang, Minghui Gong, Zhenghang Wang, Peijin Guo, Feifan Zhang, Jing Yang, Guanghao Liang, Lihui Dong, Renbao Chang, Yu Xia, Haochen Ni, Wenxuan Gong, Boyuan Mei, , Dali Han
The paper introduces UCASpatial, an ultra-precision spatial transcriptomics deconvolution algorithm, to improve the identification of immune cell subpopulations and their functional roles in tissue microenvironments.
Nature Communications · Mar 20, 2026Peer-reviewedBioinformatics