GraphESMStable: A Deep Learning Framework for Protein Stability Prediction Fusing Pre-trained Sequence Models and Graph Neural Networks
Haoyu Zhang, Zhenyu Li, Jiahao He
GraphESMStable predicts protein mutation-induced thermal stability changes using a deep learning framework combining pre-trained sequence models and graph neural networks, achieving state-of-the-art performance.
bioRxiv · Jan 9, 2026 · PreprintBioengineering