Single-cell transcriptomics uncovers chromatin dysfunction in a human TDP-43 proteinopathy model of Amyotrophic Lateral Sclerosis.
Johanna Ganssauge, Harshitha B Chandrashekar, Y H Zhang, Antonio Rocco Fusciardi, Seema Chandramohan Namboori, Akshay Bhinge
The paper uses single-cell RNA sequencing to show that TDP-43 mislocalisation disrupts chromatin remodelling in spinal neurons, identifying ACTL6B as a key inhibited factor in ALS.
bioRxiv · May 13, 2026 · PreprintNeuroscience