Proteostatic remodeling of small heat shock chaperones - crystallins by Ran-binding protein 2 and the peptidyl-prolyl cis-trans isomerase and chaperone activities of its cyclophilin domain.
Hemangi Patil, Haiqing Yi, Kyoungin Cho, Paulo A. Ferreira
This study identifies the role of Ranbp2's cyclophilin domain in regulating crystallin proteostasis and neuroprotection in the chorioretina through proteomic analysis of genetically modified mice.
ACS Chemical Neuroscience · Apr 24, 2024Peer-reviewedGenetics