PhenoBIC: operator-free single-cell spatial phenotyping in multiplex imaging data using deep learning of cell staining patterns
Abishek Sankaranarayanan, Chenkai Zhao, Hernández, Elizabeth A. Clemens, Kimberly S. Smythe, Anum S. Kazerouni, Lisa L. Carr, Christopher I. Li, Savannah C. Partridge, Shaveta Vinayak, Shachi Mittal
PhenoBIC is a deep learning model that automates cell phenotyping in multiplex imaging data, outperforming manual methods and other ML approaches with an F1-score of ~0.88.
bioRxiv · Jun 16, 2026 · PreprintBioinformatics