Coevolutionary landscape inference and the context-dependence of mutations in beta-lactamase TEM-1
Matteo Figliuzzi, Hervé Jacquier, Alexander Schug, Olivier Tenaillon, Martin Weigt
The paper develops a method to infer mutational landscapes and assesses context-dependent mutation effects in beta-lactamase TEM-1, improving explanatory power by 40% over methods ignoring epistasis.
Molecular Biology and Evolution · Oct 6, 2015Peer-reviewedBioinformatics