Clonal hematopoiesis is driven by aberrant activation of TCL1A
Joshua S. Weinstock, Jayakrishnan Gopakumar, Bala Bharathi Burugula, Md Mesbah Uddin, Nikolaus Jahn, Julia A. Belk, Hind Bouzid, Bence Dániel, Zhuang Miao, Nghi Ly, Taralynn Mack, Sofia E. Luna, Katherine P. Prothro, Shaneice Renee Mitchell, Cecelia A. Laurie, , Rasika A. Mathias
The paper develops PACER to infer clonal expansion rates from single timepoint data and identifies TCL1A activation as a mediator of clonal hematopoiesis fitness.
Nature · Apr 12, 2023Peer-reviewedGenetics