A nonsense mutant of the hepatitis B virus large S protein antagonizes multiple tumor suppressor pathways through c-Jun activation domain-binding protein1
Shu-Yi Chiu, Hsiang-Ju Chung, Ya‐Ting Chen, Min‐Syuan Huang, Chien‐Chih Huang, Shiu-Feng Kathy Huang, Isao Matsuura
This study shows that a nonsense mutant of HBV LHBs protein interacts with Jab1 to downregulate tumor suppressors p53 and Smad4, promoting HCC development.
PLoS ONE · Mar 14, 2019Peer-reviewedMolecular Biology