Detecting T cell receptor rearrangements in silico from non-targeted DNA-sequencing (WGS/WES)
Lara Lewis McGrath, Tristan J. Lubinski, J. Carl Barrett, Humphrey Gardner
The paper develops a method to estimate T cell abundance and identify TCR rearrangements from non-targeted DNA sequencing data without prior amplification.
bioRxiv · Oct 13, 2017 · PreprintBioinformatics