Molecular BiologybioRxivPreprint
JAG1 intracellular domain acts as a transcriptional cofactor that forms an oncogenic transcriptional complex with DDX17/SMAD3/TGIF2
Eun Jung Kim, Jung Yun Kim, Sung-Ok Kim…·Hyunggee Kim
The paper shows JICD1 forms a transcriptional complex with DDX17, SMAD3, and TGIF2 to increase SOX2 expression, promoting cancer stem cell properties and tumorigenicity.
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