Telomerase deficiency in humans is associated with systemic age-related changes in energy metabolism
E. N. James, V. Sagi-Kiss, M. Bennett, M. Mycielska, K.-N. Lee Pemg, T. Roberts, S. Matta, I. Dokal, J. G. Bundy, E. K. Parkinson
This study identifies systemic metabolic changes in telomerase-deficient patients, showing that pyruvate and lactate levels distinguish Dyskeratosis Congenita from controls, suggesting metabolic shifts linked to telomere dysfunction.
bioRxiv · Feb 28, 2022 · PreprintCell Biology