Amplification of genomic regions harbouring genes with dose-limiting effects provides selection pressure for acquiring aberrant epigenetic silencing in ovarian cancer
N. Bonito, I. Eringyte, N. Masrour, C. S. Wilhelm-Benartzi, R. Brown, E. Curry
The paper shows that genomic copy number gains in ovarian cancer are associated with promoter methylation, which suppresses gene expression, and demonstrates this through functional experiments.
bioRxiv · May 7, 2019 · PreprintCancer Biology