A generative algorithm for de novo design of proteins with diverse pocket structures
B. Basanta, M. J. Bick, A. K. Bera, C. Norn, C. M. Chow, L. P. Carter, I. Goreshnick, F. Dimaio, D. Baker
This paper introduces a generative algorithm for designing de novo proteins with diverse small molecule binding pockets, validated through experimental testing and showing improved stability and diversity compared to natural proteins.
bioRxiv · Mar 23, 2020Biochemistry